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Tumour Promoting Potentials of HAART backbone (NNRTIs and NRTIs) leading to increase cancer risk among AIDs patients

ZAKARI Aisha

Department of Health and sport, University of East London, London, United Kingdom,Current Address: Fabson close, Kagoro bye Express, Kaduna State, Nigeria,Telephone: +2348068423974

Abstract

Introduction:

Since the discovery of AIDS in 1980, the development of cancers has featured as a major problem in HIV patients. The extents of malignancies kept increasing among HIV infected population than the normal population. HAART widely became available in the 1990s, and has marked a notable decrease in the occurrence of diseases and death rate in HIV infected population but long-term use of it have been associated with increase cancer risk. Therefore, it will be of significance important to study the tumour promoting potentials of HAART Backbone (NNRTIs and NRTIs) leading to increase cancer risk in HIV infected population.

Method:

Cell differentiation potential was evaluated using U937 cells exposed to Nevirapine (NVP), Abacavir Sulphate (ABC) and Zidovudine (AZT) for 72hrs. Also, DNA breakage induced by NVP, ABC and AZT on HeLa cells at 40ug/ml and 50ug/ml using a modified FADU protocol was evaluated.

Results:

The highest transforming ability was recorded with AZT 50ug/ml as 98% of treated cells transformed into adherent cells after 72hrs exposure as compared to untreated cells. DNA breakage was not induced with NVP, ABC and AZT concentrations used on cells for 4hrs (40 and 50ug/ml).

Conclusion:

Overall, the research suggests that NVP, ABC and AZT have cell differentiation potential concluding that these drugs have tumour promoting potentials leading to increase cancer risk.

Keywords

Tumour promoting potential, DNA Damage, HAART classes, AIDs, Cancer

How to cite this article

Z Aisha*Microbioz Journals, Journal of Microbiology
and Biomedical Research 4 (3)

Article Details

Type of article

Original Artilcle

Date of publication

16/08/2018

Mode of access

Open Access

Correspondance

Department of Health and sport, University of East London, London, United Kingdom,Current Address: Fabson close, Kagoro bye Express, Kaduna State, Nigeria,Telephone: +2348068423974

Email ID: aishazakz@gmail.com

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